Coexistence of ampulla Vater tumor and Castleman's disease: a rare case report

Castleman's disease (CD), which is localized in the pancreatic region, is a rare clinical condition, and it is usually quite difficult to diagnose it and to distinguish it from pancreatic malignancies and pancreatic adeno- carcinoma metastases. Here, a 58-year-old patient with dyspeptic complaints was presented, and a periampullary localized 3x3.5 cm diameter tumor and periportal, celiac, portacaval localized multiple lymphadenomegaly were detected by EUS and computerized tomography (Figure 1). Benign cytology was detected by EUS-guided biopsy. The patient underwent pancreaticoduodenectomy (Whipple procedure) (Figure 2). Histopathological examination showed poorly differentiated adenocarcinoma in the ampulla vater, and 19 lymph nodes with diameters ranging from 2.5 to 7.5 cm were mixed type CD and that none of them had metastasis. The patient has been followed without any problem for 11 months.